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Description

For drugs bound to albumin covalently, the mode of cellular uptake has been shown to occur via caveola-mediated endocytosis e.g., in case of Abraxane, JNTX-101 (albumin-encapsulated gemcitabine), SSH20 (7-ethyl-10-hydroxy-camptothecin conjugated to albumin), and IPBA-DOX (doxorubicin conjugated to 4-( p -iodophenyl) butyric acid) [30,31,32,33]