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Expert Opin Ther Pat 30(6):389407

"This is not a question of whether Americans will use peptides," he added

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Accordingly, for clinical-stage PROTACs, selectivity is more appropriately understood primarily at the levels of target engagement and degradation profile, whereas strict cell-type selectivity is not generally considered an intrinsic property

Biochem Pharmacol 222:116102 Zhang Y et al (2024) Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy