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Digestive enzyme deficiencies : These could affect B12 release from food, further hindering absorption

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Several molecules involved in the signal transduction processes, including small GTP-binding proteins and tyrosine kinases, such as c-Src, c-Yes, and protein kinase C (PKC), have been found to be localized at these tight junctions, presumably indicating their pivotal role in the maintenance of tight junction integrity 54,55