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(Bravo and Anacona, 2001

Although, like other SLC22 family members, SLC22A4 is capable of transporting multiple substrates, the transport efficiencies for other confirmed substrates are orders of magnitude lower than that of ergothioneine, and increasing evidence from independent laboratories demonstrates SLC22A4 is highly specific for ergothioneine (Reference Yee, Buitrago and Stecula28,Reference Tschirka, Kreisor and Betz31,Reference Tucker, Cheah and Halliwell32)

Such cells are more sensitive to glutamine metabolism inhibitors and mitochondrial poisons

Numerous preclinical studies have also suggested that tocotrienols might be beneficial in the prevention of chronic diseases (12)

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These combined data are used to predict individual fertility risk and to guide personalized treatment strategies, particularly in the context of assisted reproductive technologies