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Animal studies have found that calycosin can improve spatial studying and memory and up-regulate the expression of synaptic proteins and brain-derived neurotrophic factor (BDNF) in the hippocampus of diabetic rats, and this effect may be associated with up-regulation of SOD, GSH-Px levels and down-regulation of MDA levels through the regulation of PI3K/Akt/glycogen synthase kinase 3 (GSK-3) pathway (61)

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Glutathione depletion is accompanied by increased neuronal nitric oxide synthase activity

Now the commissions capital plan for 2025 through 2031 shows a projected $156 million investment in replacements and repairs of water mains