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Among these hypotheses about the mechanisms of sustained antidepressant effect, several studies have highlighted that the focus of the mechanism of sustained antidepressant pharmacodynamics should be centered on the downstream, long-term events of change induced by sustained antidepressant action

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Indeed, Sp was able to restore cytosolic and mitochondrial redox balance in neuronal cell line SHSY-5Y subjected to 1-methyl-4-phenylpyridinium (MPP + ) treatment which is known to cause mitochondria dysfunction and oxidative stress through complex I inhibition 1 (Fig

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