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Description

"No approved application pursuant to section 505 of the FD&C Act, 21 U.S.C

Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments

Statements Author contributions CX: Conceptualization, Writing original draft

Objective: Here, we investigated whether histone deacetylase 8 (HDAC8) contributes to tight junction (TJ) disruption in AR by modulating Smad7 acetylation