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Within this environment, cytotoxic and effector immune cells experience oxidative exhaustion and loss of function, whereas immunosuppressive subsets are favored and maintained

Shikonin circumvents cancer drug resistance by induction of a necroptotic death

This can be attributed to the incorporation of pAcF at the mutation sites, as PV2-S71pAcF and PV3-N77pAcF enhanced the thermal stability by 5 o C and 8 o C, respectively (Fig