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It results in increased expression of cytochrome c, which forms apoptosomes with Apaf-1 and pro-caspase-9, subsequently reducing the levels of the anti-apoptotic protein Bcl-2 and promoting tumor cell apoptosis [248]

Fujikawa, S

10.3390/molecules23102598 80 TatipamulaV

Adv Med Sci

Mol Biol 47(4):515523 Lu SC (2001) Regulation of glutathione synthesis

In fungi, the Gst isoform number is ranged from 4 gene copies in the basidiomycete yeast Sporobolomyces roseus to 44 gene copies in brown rot fungi Postia placenta and Coniophora puteana 33