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Preclinical Onset Data (Animal Models Not a Human Timeline) The cleanest independent support for Dihexa is a 2021 study from a Chinese group (Sun et al., Brain Sciences, PMID 34827486) in APP/PS1 Alzheimer's-model mice

2.1.3.2 The GCH1/BH4/DHFR axis Guanosine triphosphate (GTP) cyclohydrolase 1 (GCH1) catalyzes the initial step in the biosynthesis of tetrahydrobiopterin (BH4), a process that also involves 6-pyruvyl tetrahydrobiopterin synthase (PTPS) and sepiapterin reductase (SPR)

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Both MDG and MLG showed more significant weight loss compared to the control group