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The 5 mg/kg intraperitoneal dosing regimen (three times weekly) established the preclinical dosing framework for subsequent research

Modern methods of 16S rRNA sequencing and metagenomic analysis provide high-resolution insights into the microbiota, allowing the identification of specific profiles associated with diabetes and enabling the development of personalized dysbiosis-correction strategies

Identification and classification of papain-like cysteine proteinases

It works primarily by binding to the ghrelin receptor (GHS-R1a)

Not all patients are candidates, and individual responses vary

Korkushko OV, Khavinson VKh, Shatilo VB, Antonyuk-Shcheglova IA