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Antecedent cellular mechanisms The essence of human aging is cellular senescence, senescent cells forever out of the cell cycle, but they will not be removed as directly as apoptotic cells, senescent cells generally have a large number of damaged DNA, which may be the reason why they are not removed, so the senescent cells will be a large number of retained, and continue to be deposited thereby inducing the bodys aging and the occurrence of related diseases

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In addition, some studies link TLR4 with changes in the gut barrier function