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The subsequent hydrolysis of the acylCoA compound to its free acid results in acidosis which can be life-threatening

Obesity leads to hypertrophy of hepatocytes, leading to the activation of transcription factors that, some research shows, promote gallstone formation[18]

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Steady state in both the mouse and human model was calculated with a fixed palmitoyl-CoA concentration of 25 M, which was the substrate of the model, unless indicated otherwise

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