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Key areas include the left temporoparietal, occipitotemporal, and fusiform gyrus, which are crucial for decoding and recognizing written words

Lastly, although the following genes are implicated in AD at late stages, we did not find differences between Wt and Tg expression of Ape1 137,138 , Cdk5 137,139,140,141,142,143 , Parp1 105 , Pcna 144,145 , Pol 146,147 , or Sirt3 148,149,150 ,

Neurobiology of Aging, 27(2), 318-323

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[DOI] [PMC free article] [PubMed] [Google Scholar] 202.Muhammad N, Lee HM, Kim J

Key Research Findings HGF/c-Met Receptor Activation Facilitates dimerization of the hepatocyte growth factor receptor, activating downstream PI3K/Akt and MAPK/ERK signaling cascades involved in neuronal survival Synaptogenic Activity Preclinical research demonstrated promotion of new dendritic spine formation and synaptic connections in hippocampal neurons at picomolar concentrations Cognitive Research Animal studies showed enhanced performance in spatial learning and memory tasks (Morris water maze, radial arm maze) in models of cognitive impairment Blood-Brain Barrier Penetration Unlike parent angiotensin IV peptides, Dihexa was engineered for oral bioavailability and CNS penetration Neurotrophic Factor Modulation Research suggests amplification of endogenous HGF signaling rather than direct receptor activation, potentiating existing neurotrophic pathways Specifications Reported Side Effects in Research Limited safety data