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Begin prioritizing 7-8 hours of quality sleep nightly at least two weeks before starting therapy

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Funding The authors declare that financial support was received for the research, authorship, and/or publication of this article

What the mechanism does NOT prove: Even if all the proposed mechanisms are real, they have been demonstrated primarily in animals or in vitro

M., Thuren, T., Zalewski, A

Dihexa half life (one to three hours) measures the time required for plasma concentrations to decline by 50%, while therapeutic window refers to the duration during which receptor activation drives neuroplasticity changes which extends for hours beyond plasma clearance