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It is characterized by excessive keratinocyte proliferation, resulting in the formation of scaly, erythematous plaques (Damiani et al

The studies showed no clear evidence that HSCT improved outcomes when 1) transplanting all patients with hypodiploid ALL, or 2) transplanting hypodiploid patients deemed at high risk on the basis of high MRD after induction

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There are two main factors that contribute to these observations

Collagenase is an enzyme that breaks down collagen in damaged tissues to help the body create new, healthy tissue