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Ferroptotic injury promotes the release of pro-inflammatory mediators and amplifies oxidative stress (79), which can aggravate microcirculatory dysfunction and hypoxia, thereby reactivating HIF programs and further perturbing iron handling

It's been studied extensively over the last few decades and has shown promise in treating some medical conditions, including inflammation, ulcers, pain, and more

Regulation of Nrf2/ARE pathway by dietary flavonoids: a friend or foe for Cancer management

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Autophagy 2014