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KEGG pathway analysis further indicated that these upregulated DEGs were enriched in glycine, serine and threonine metabolism and glyoxylate and dicarboxylate metabolism ( Figure 5B ), implying that biogas slurry treatment may enhance one-carbon metabolism to provide precursors for nucleic acid and amino acid synthesis

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The intrinsic pathway is activated by the oligomerization of the BCL2 family protein BAK and BAX, which contributing to the formation of oligomers from pores in the mitochondrial outer membranes, leading to the release of cytochrome c into the cytosol

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