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Hu W, MacDonald ML, Elswick DE, Sweet RA (2015) The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies

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A fitness score ( s MUT ) was calculated for each variant as ln( MUT / STOP )/ln( SYN / STOP ), where MUT is the enrichment ratio calculated for each variant, STOP is the median enrichment ratio of all nonsense variants, and SYN is the median enrichment ratio of all synonymous variants, such that s MUT = 0 when MUT = STOP and s MUT = 1 when MUT = SYN

10.1371/journal.pone.0017479 11 BrennerD

10.3390/nu10020147 53