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IC50 values (the concentration required to inhibit 50% of enzyme activity) for 5-Amino-1MQ against NNMT are in the low micromolar range (approximately 25 M in published in vitro assays), while IC50 values for structurally related methyltransferases are orders of magnitude higher, suggesting high specificity

PMID:2714159 Pearlman SA et al

SLC7A11 inhibits ferroptosis by increasing intracellular cystine and promoting glutathione synthesis (Dixon et al., 2012)

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Nrf2/Keap1/ARE signaling: towards specific regulation

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