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Together, this evidence suggests that while mutations or inadequacy of DNA repair mechanisms may play a role in promoting cancer neogenesis and progression, these deficiencies may increase sensitivity of cancer to therapy

Alamanos Y, Drosos A

The ROS overproduction results in oxidative impairment of lipids, proteins, and DNA (53), where the accumulation of DNA damage induced by ROS may lead to genetic destabilization in the case of cancer, thus facilitating the development of cancer (54)

Pain occurs two or three times more frequently in patients with PD than in individuals of similar age without PD 38 , 39 , 40

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AE collected articles and wrote the first draft of manuscript, JWG initiated the study and revised the manuscript and TLW finalized the manuscript