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This could be caused by a general imbalance in the levels of several hormones, including lower levels of leptin and visfatin and higher adiponectin in NF1 patients with respect to control subjects

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A random forest classification model was applied on the16S rRNA abundance analysis, revealing that Ruminococcus gnavus, Clostridium ramosum, and Bifidobacterium longum were highly enriched in gut microbiota composition during the tolerant (smooth) state compared to the rejection state in post-transplantation period (Figure 1A)

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CKD is not only an important contributor to morbidity and mortality from non-communicable diseases, but also an important risk factor for cardiovascular disease (Collaboration, 2020)

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