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Administration of a GSH inhibitor into nucleus accumbens impairs PR test performance To assess whether decreasing local accumbal GSH levels alters motivated performance, rats were injected with either BSO (an inhibitor of gamma-glutamylcysteine synthetase-the rate-limiting enzyme for GSH synthesis) at 7 g/l or DMSO (the diluent of BSO) intra-NuAc (1 l per hemisphere) (Figure 4a and 4b)

These unique macrocycles presented low micro- to submicromolar EC 50 values, indicating promising anti-SARS-CoV-2 activity

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In: Agrawal, D., Dhanasekaran, M

The diversity of the molecules metabolized by these enzymes is a defining feature, and a single CYP has the potential to metabolize multiple different drugs