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Circ_0000745 interference has also been shown to inhibit the cell cycle and glycolysis and increase the levels of intracellular iron and lipid ROS induced by erastin, thus accelerating ferroptosis (Yang et al., 2022)

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doi: 10.3390/antiox10091442 118

At the AACR 2026, a poster presented by Crown Bioscience demonstrated how genOways hSA/hFcRn mice (genO-hSA/hFcRn), enable a predictive, humanrelevant PK assessment of ADCs across diverse linker and payload formats, showing how this model could be an alternative to replace the use of non-human primates (NHPs)