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Across chemotherapy, targeted therapy and immunotherapy, primary and acquired resistance and subsequent relapse remain common

In this context, the use of 5-MTHF, the bioactive form of folate, emerges as a promising alternative to folic acid

Our roGFP2 measurements confirm (i) that dynamic roGFP2 sensing (or the physiological glutathionylation/deglutathionylation of regular surface-exposed cysteinyl residues) requires a glutaredoxin activity, and (ii) that glutathionylated proteins or metabolites should be very transient redox species when GSH and glutaredoxins are present (unless they are stabilized by a kinetic uncoupling mechanism) 5,32,34,35,61,62,63,64