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17 More than 40 drug substrates have since been identified for the GI microbiota, 5,1821 highlighting the ability of gut microbes to perform diverse chemical transformations on drugs, including reduction, hydrolysis, the removal of a succinate group, dehydroxylation, acetylation, deacetylation, the cleavage of a N-oxide bounds, proteolysis, denitration, deconjugation, thiazole ring opening, deglycosylation and demethylation

thereby it results in the failure of autophagic flux [52]

Current treatment options in neurology, 10(6), 410419

the activity of serum SOD enzymes was significantly increased

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(2) neurodegenerative disease