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Tetrathiomolybdate inhibits copper trafficking proteins through metal cluster formation

Mitochondria are essential for CAR-T cells, and strategies targeting mitochondrial metabolism, such as increasing mitochondrial biomass, enhancing mitochondrial activity with OXPHOS, upregulating mitochondrial plasticity, and so on, have been proposed to reduce mitochondrial plasticity in CAR-T cells

Cytidine and choline are believed to individually cross neuronal cell membranes and facilitate PtdCho synthesis

doi: 10.1007/s00125-020-05262-w 53 HoKKOSullivanAJHoffmanDM

Results: Data is currently available for 11 patients with at least 4 weeks of REP 2139-Mg exposure

There are two states of glutathione in the cells: reduced glutathione (GSH) and oxidized glutathione disulfide (GSSG)