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Reconstitution: Add 3.0 mL bacteriostatic water ~3.33 mg/mL concentration Typical Daily Dosage Range: 300800 mcg (gradual titration recommended) Measurement Guide: 1 unit 33.3 mcg (U-100 insulin syringe) Storage: Lyophilized: 20C (4F) Reconstituted: 28C (35.646.4F) Avoid freezethaw cycles Dosing & Reconstitution Guide Educational guide for reconstitution and daily dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Once daily via subcutaneous injection

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CC-3), DNA damage (-H2AX) and suppressing microtubule dynamic instability (Extended Data Fig