cjc + ipamorelin CJC-1295 (Mod GRF 1-29) & CJC-1295 (No DAC) 5mg, Ipamorelin

They create an immediate lifting effect, while also triggering a healing response that boosts collagen and elastin over time

Disclosures: Arunkumar Krishnan: Nothing to Disclose, Diptasree Mukherjee: Nothing to Disclose, Carolin Schneider: Nothing to Disclose, Tinsay Woreta: Nothing to Disclose, Saleh Alqahtani: Nothing to Disclose 1161 NOTCH SIGNALING DISRUPTION AND CELLULAR CROSSTALK: DISSECTING THE PATHOPHYSIOLOGY OF BILE DUCT PAUCITY IN ALAGILLE SYNDROME USING HUMAN LIVER ORGANOIDS Marie-Agns M'CALLUM 1 Quang Toan PHAM 1 Kristen Vieira-Lomasney 1 Eytan Haddad 1 Silvia Selleri 1 Massimiliano Paganelli 1 , 1 Liver Tissue Engineering and Cell Therapy Laboratory, CHU Sainte-Justine, Universit de Montral Background: Alagille syndrome (ALGS) is a multisystemic genetic disorder resulting in severe liver disease characterized by intrahepatic bile duct paucity

J Biol Chem 233: 11351139

Caspase-1/11, cysteine-aspartic protease 1/11

Tedeschini E, Levkovitz Y, Iovieno N, Ameral VE, Nelson JC, Papakostas GI

That unexpected result drove us to test lower concentrations in a dose-response manner