10.1016/j.cmet.2022.05.004 73 MllerT
Dihydrofolate reductase In addition to key roles in folate metabolism, dihydrofolate reductase (DHFR
In the production of cosmetics, due to its complete water solubility, it is extremely convenient to add and non-irritating, making it suitable for sensitive skin
Abbreviations PD: Parkinsons disease -syn: Alpha-synuclein GI: Gastrointestinal CNS: Central nervous system ENS: Enteric nervous system DBS: Deep brain stimulation FMT: Fecal microbiota transplantation SNpc: Substantia nigra pars compacta 6-OHDA: 6-hydroxydopamine MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Paraquat: 1,1-dimethyl-4,4-bipyridinium dichloride Maneb: Manganese ethylene-1,2-bisdithiocarbamate MSA: Multiple system atrophy EOPD: Early onset Parkinsons disease ROS: Reactive oxygen species OS: Oxidative stress LRRK2 : Leucine-rich repeat kinase 2 LRR: Leucine-rich repeats Roc : Ras of complex proteins COR: C-terminal of Roc WT: Wild type CR: Calretinin CB: Calbindin MPP+: 1-methyl-4-phenyl-2,3-dihydropyridinium ion RNA: Ribonucleic acid DNA: Deoxyribonucleic acid BBB: Blood-brain barrier EBDC: ethylene-bis-dithiocarbamate DA: Dopamine MAO: Monoamine oxidases NADPH: Nicotinamide adenine dinucleotide phosphate LB : Lewy bodies DLB: Dementia with Lewy bodies LNs: Lewy neurites vSNARE: (v)-soluble N-ethylmaleimide sensitive factor attachment protein receptor SV: Synaptic vesicle VMAT2: Vesicular monoamine transporter 2 TH: Tyrosine hydroxylase L-DOPA : L-3,4-dihydroxyphenylalanine AADC: Aromatic L-amino acid decarboxylase DAT: Dopamine transporter DBH: Dopamine -hydroxylase CRE: cAMP response element NET: Norepinephrine transporter SERT: Serotonin transporter CMA: Chaperone-mediated autophagy TKO: Triple knockout PFF: Preformed fibrils NMDA: N-methyl-D-aspartate EAAT1: Excitatory amino acid transporter 1 AMPA: -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid VGLUT: Vesicular glutamate transporter GLP-1 : Glucagon-like peptide 1 EECs: Enteroendocrine cells IBS: Irritable bowel syndrome ASD: Autism spectrum disorder AD: Alzheimers disease ANS: Autonomic nervous system IECs: Intestinal epithelial cells DSS: Dextran sulfate sodium SIBO: Small intestinal bacterial overgrowth CCR2: Chemokine receptor type 2 LPS: Lipopolysaccharide IL-1 : Interleukin-1 IFN- : Interferon-gamma LBP: Lipopolysaccharide-binding protein SCFAs: Short chain fatty acids TLR4 : Toll-like receptor 4 NaB: Sodium butyrate HDACi: Histone deacetylase inhibitor TPH1: Tryptophan hydroxylase ECs: Enterochromaffin cells FFAR: Free fatty acid receptors GPCRs: G-protein-coupled receptors SSRIs : Selective serotonin reuptake inhibitors GABA: Gamma-aminobutyric acid BAs: Bile acids FXR: Farnesoid X receptor TUDCA: Tauroursodeoxycholic acid JNK: c-Jun N-terminal kinase Nrf2: Nuclear factor erythroid 2-related factor 2 GPX: Glutathione peroxidase UDCA: Ursodeoxycholic acid RCTs : Randomized controlled trials GLP-1 : Glucagon-like peptide-1 NAD+ : Nicotinamide adenine dinucleotide NR: Nicotinamide riboside GPi: Globus pallidus interna STN: Subthalamic nucleus iPSCs : Induced pluripotent stem cells siRNA: Small interfering RNA ASO: Antisense oligonucleotide References W Poewe K Seppi CM Tanner GM Halliday P Brundin J Volkmann AE Schrag AE Lang 2017 Parkinson disease Nat Rev Dis Primers 3 17013 A
Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation
Recent advancements in immunotherapy are exploring alternatives beyond avoidance, aiming for long-term desensitization
