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27 Approximately 9% of gastric cancer (GC) patients are EBV-positive, and these cases have a distinct molecular phenotype and clinical characteristics

Hagiwara, A

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It activates the SIRT1/peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) pathway to promote mitochondrial biogenesis, regulate mitochondrial homeostasis, and inhibit the high mobility group protein (HMGB)1/TLR4/p38/extracellular regulated protein kinases (ERK)1/2 pathway to reduce inflammatory responses in CIA mice (259)

Chronic sleep loss is associated with reduced intracellular glutathione levels and increased lipid peroxidation, shifting cells toward an oxidized redox state and increasing vascular and metabolic vulnerability (22)

These results show that H 2 O 2 -induced oxidative stress in cells leads to decreased viability, increased mtROS, reduced ATP levels, and downregulation of oxidative phosphorylation (OxPhos) genes, consistent with the changes induced by noise exposure in vivo