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Metabolic profiling, as an "overall model", has high specificity and can distinguish patient populations from healthy populations with considerable accuracy

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Other secondary causes of cognitive impairment, including genetic disorders (e.g., Wilsons disease), autoimmune conditions (e.g., SLE), chronic epileptic syndromes, repetitive head trauma (e.g., chronic traumatic encephalopathy) [501], and neoplastic processes or their treatments (e.g., chemotherapy-related cognitive impairment or brain fog) [502], are similarly well defined

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