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Methods Study design and sampling strategies We used the 20152016 NHANES survey data by the National Center for Health Statistics of the Centers for Disease Control and Prevention (CDC) in the US for this study [31]

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As citrullination is considered one of the crucial steps in the development of RA, and also as ACPAs seem to be involved in the progression of RA, new pharmaceutical agents targeting PADs have been investigated: PAD inhibitors including F-amidine (the most potent known inhibitor), paclitaxel and 2-chloroacetamidine [40]

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