conjugation toxins to glutathione 14 Formation of a reactive metabolite by Glutathione-Mediated Conjugation of Anticancer Drugs:

these showed that increased cellular GSSG accumulation, rather than GSH reduction, rendered hepatocytes susceptible to TNF-induced cytotoxicity

doi: 10.1038/s41577-019-0198-4 191 TranT

Many different conditions affect the contents of intracellular GSH, some of them are the presence of heavy metals, high glucose concentrations, protein malnutrition, thermal shock, exposure to reactive oxygen and nitrogen species including, H 2 O 2 and nitric oxide, ozone exposure, ionizing radiation, and cigarette smoke [37,40,61,73,81]

Glutathione therapy is not meant to act as a substitute for professional medical care and treatment of serious illnesses or conditions

doi: 10.1038/nn1765

Virtually every person with disease-related frailty is depleted in glutathione