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MTHFR mutations are commonly associated with high homocysteine levels 3 and low methionine production, which in turn may lead to the accumulation of S-adenosylhomocysteine (SAH) and low levels of SAMe

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However, though resveratrol is known to prevent oxidative stress in human lens epithelial cells, its effects on lens stiffness and the progression of the near vision impairment remain unknown