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The p53 pathway is an important regulatory pathway that is often broken in SCLC

Akwaa F, Liesveld J Leukemia & lymphoma

Functional implications: Increased resistance to carboxypeptidase degradation

However, the inverse redox dynamics of the two pools indicate that the coupling between the NADP redox state and E GSH is disrupted and equilibration via GR1 is limiting

Symptoms may include (9): Fatigue Nausea, weight loss, little or no appetite Abdominal pain or pain below the right ribcage Jaundice (yellow tinge of skin and eyes from bilirubin not being removed from the blood by the liver) Edema (swelling of the legs and extremities) Ascites (painful, abnormal swelling of the abdomen) Disorientation or confusion Risk Factors for Non-Alcoholic Fatty Liver Disease Many factors can increase the risk of developing a fatty liver, and although the exact causes of non-alcoholic fatty liver have not been determined, numerous risk factors have been identified (5)

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