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Our investigation started by examining ALA's role in human health, for which we reviewed several dozen research studies, scientific papers, and clinical trial results to understand its mechanisms, effective dosages, and potential benefits

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The pathogenic allele of GRM7 changes the synaptic autoregulation of glutamate in the synaptic fissure of the sensory cells of the IHC and auditory neurons, leading to an increase in the level of glutamate in the fissure, followed by the death of excitotoxic neurons and/or sensory cells [49]