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Moreover, Li et al (65) have recently identified a high frequency of KIR + CD8 + T cells in blood and inflamed tissues of patients with autoimmune diseases, which are similar to Ly49 + CD8 + T cells with regulatory function in mice

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CSD has been demonstrated to activate the trigeminovascular system (TVS) both centrally and peripherally by exposing the dura to inflammatory molecules, indicating that susceptibility to CSD may contribute to the initiation of migraine attacks (26, 27)