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Pharmacotherapy19196204

doi: 10.5056/jnm.2011.17.2.131 8 AfariNAhumadaSMWrightLJMostoufiSGolnariG

Mitochondria affect ferroptosis at the level of the cytosolic iron pool regulation by fine-tuning the iron influx from the cytosol into mitochondria, at the level of electron transport chain by adjusting mitROS generation and oxidative phosphorylation via AMPK activation in the energy-deficient state, and at the level of tricarboxylic acid (TCA) cycle affecting the content of NADPH and GSH [162, 166]