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N Engl J Med 343 : 923930 Mauras N et al

NAD+ itself is essential to cell metabolism, but high quality human studies on injected low doses are still limited

Related work showed context-appropriate angiogenesis during muscle/tendon healing, with VEGF-linked markers in vivo (Brcic 2009)

However, like other supplements, upset stomach, headaches, pain at the site of injection, reddening, swelling, and other discomforts at the point of injection are also positive