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Influence of caloric intake on experimental carcinogenesis: a review

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42, 43, 44 In addition, knockout mice that lack a crucial subunit of the GCL enzyme show significant reduction of glutathione levels in the anterior cortex, 45 especially during the prepuberal period, which is followed by SZ-like behaviour in the time frame of disease onset 46 and SZ-like neural changes in the hippocampus (HIP) of the adult knockout mice, including an increase in oxidative stress and a decrease in the number of parvalbumin (PV) interneurons

Cell Host Microbe (2020) 27(2):22537.e8

However, non-genetic resistance mechanisms are also crucial, particularly the formation of drug-tolerant persister (DTP) cells (13, 15, 16)