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The most responsible framing is: Short-term tolerability is not the same as long-term safety Manufacturing quality heavily affects risk People with medical conditions or those taking medications should talk to a clinician before considering unapproved substances

As with any supplement, intake should be tailored to individual needs, dietary patterns, and health status

Nothing is ruined you simply get a lower concentration

Ive maintained my exercise routine, including 2.5M runs a few times a week and it hasnt seemed to cause any issues with these, though I was a little worried about it

As we age, B12 levels tend to decline, and low B12 levels and high homocysteine levels have been linked with dementia onset as well as several inflammatory diseases, but B12 injections restore B12 to healthy levels and reduce homocysteine (making it also beneficial for cardiovascular disease)-- see the infusions page for more info