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This typically involves: Intrinsic factor antibodies (highly specific for pernicious anaemia, though sensitivity is only 50%) [12] [28] Gastric parietal cell antibodies (more sensitive but less specific) Coeliac serology if malabsorption is suspected Consideration of upper gastrointestinal endoscopy in selected cases, particularly with autoimmune gastritis/pernicious anaemia NICE guidance emphasises that treatment should not be delayed whilst awaiting antibody results if clinical features strongly suggest deficiency, as irreversible neurological damage can occur

Intercellular and intracellular location of ATP sulfurylase, cysteine synthase and cystathionine b -lyase in maize leaves

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While B12 itself does not directly cause weight loss, its role in energy production and metabolism means it can support weight management by ensuring your body has the energy it needs to stay active