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Clofarabine, Idarubicin, and Cytarabin (CIA) As Frontline Therapy for Patients Younger Than 61 Years with Newly Diagnosed Acute Myeloid Leukemia (AML)
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By 2020, DON had advanced through phase III clinical testing in more than 700 patients, but dose-limiting gastrointestinal toxicity and limited efficacy curtailed further development [167]

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LT2MYC mice from three separate litters were induced at 8 weeks of age, by taking mice off doxy chow