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Combining FXR and PPAR agonists may provide synergistic effects in controlling cholesterol-driven metabolic dysfunction and MASLD-related inflammation [40]

doi: 10.1016/j.fbio.2022.101894 42

It has been recently shown [60] that T cells from depressed patients displayed a compromised metabolic profile accompanied by heightened gene expression of CTP1a (carnitine palmitoyltransferase 1 A), the mitochondrial enzyme responsible for ACs synthesis

Thus, berberine combined with atorvastatin may be an efficient therapeutic method to treat atherosclerosis

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