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However, resistin is known to promote IL-23/Th17 inflammation in various experimental models and to regulate the homeostasis of Treg cells [125, 148]

Since tirzepatide may slow gastric emptying as part of its mechanism of action, patients with pre-existing severe gastroparesis could experience worsening of symptoms, including nausea, vomiting, and potential complications related to delayed gastric emptying

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On one hand, it means the compound doesn't accumulate to potentially unwanted levels over long periods

[DOI] [PubMed] [Google Scholar] 40.Qi C., Zhou J., Wang Z., Fang X., Li D., Jin Y., Song J