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Accessed November 16, 2017

Biomed J 2023:100609

Indeed, glutamine-derived R-2-HG accumulates and prevents the differentiation of myeloblasts, resulting in uncontrolled growth of blood cells 122

doi: 10.1038/s41467-017-00145-y 232 LiCCMunalisaRLeeHYLienTSChanHHungSCet al

Its major biochemical characteristics include increased soluble iron, elevated ROS generation, reduced GPX4 activity, and accumulation of lipid metabolites [53]