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Cellular stress induced by either stress or SUD plays a significant role in this process, offering potential therapeutic targets

Polyphenols: Mechanistic Basis and Evidence Polyphenols, a diverse group of plant-derived secondary metabolites encompassing flavonoids, phenolic acids, stilbenes, and lignans, exhibit potent antioxidant and regulatory properties that promote cellular protection and longevity [193,194,195]

As of April 2023, a PubMed literature search utilizing the MeSH keywords [Periodontal Diseases/Prevention & Control] and [Biological Products] generated 1458 items (Figure 4)

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2.4 Statistical analysis We used R (version 4.1.2, R Foundation for Statistical Computing, Vienna, Austria) for data analysis and figure plotting

Blood 88(10):161b, 1996