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Hasani et al., 2024)

PMC 5809909

The enzyme soluble epoxide hydrolase (SEH) rapidly converts EETs into dihydroxyeicosatrienoic acids (DHETs), which reduce vasodilation

After 1 week of acclimatization period, animals were segregated into four groups ( n = 6 in each group) viz, Control, Mito-TEMPO, 5-FU and 5-FU + Mito-TEMPO

The dose depends on the formulation: 1.4 mg daily for Egrifta SV, 1.28 mg daily for Egrifta WR, or 2 mg daily for research vials (matching the original Phase III trial dose)

MG therapy should be ambitious and aim for clinical remission or only mild symptoms with near-normal function and quality of life