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Budesonide has a better safety profile than Fluticasone for pneumonia risk and should be preferred, but the dose should be kept to its minimum, and whenever possible should be withdrawn

Here we show that MYCN induces massive lipid peroxidation on depletion of cysteine, the rate-limiting amino acid for glutathione (GSH) biosynthesis, and sensitizes cells to ferroptosis, an oxidative, non-apoptotic and iron-dependent type of cell death

Studies have shown that ROS fosters vascular injury by promoting phenotypic switching and apoptosis of VSMCs (78, 79), while the inhibition of ROS reverses this effect (80)

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